| 1. |
神経保護関連 (Neuroprotection) |
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Cellular and molecular effects of unoprostone as a BK channel activator. |
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Cuppoletti J, Malinowska DH, Tewari KP, Chakrabarti J, Ueno R. |
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Biochim Biophys Acta. 2007 May;1768(5):1083-92. (Also see Mechanism) |
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Unoprostone isopropyl rescues retinal progenitor cells from apoptosis in vitro. |
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Mukuno H, Nakamura M, Kanamori A, Nagai A, Negi A, Seigel G. |
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Curr Eye Res. 2004 Dec;29(6):457-64. |
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Neuroprotective properties of a synthetic docosanoid, unoprostone isopropyl: clinical benefits in the treatment of glaucoma. |
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Melamed S. |
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Drugs Exp Clin Res. 2002;28(2-3):63-73. Review. |
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Photoreceptor protection against constant light-induced damage by isopropyl unoprostone, a prostaglandin F(2alpha) metabolite-related compound. |
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Hayami K, Unoki K. |
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Ophthalmic Res. 2001 Jul-Aug;33(4):203-9. |
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| 2. |
血流関連 (Ocular Blood Flow) |
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a) 動物眼 (Animal eyes) |
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Effect of unoprostone on topographic and blood flow changes in the ischemic optic nerve head of rabbits. |
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Sugiyama T, Mashima Y, Yoshioka Y, Oku H, Ikeda T. |
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Arch Ophthalmol. 2009 Apr;127(4):454-9. (Also see Anti-Endothelin Function) |
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Effects of topical travoprost and unoprostone on optic nerve head circulation in normal rabbits. |
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Ohashi M, Mayama C, Ishii K, Araie M. |
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Curr Eye Res. 2007 Sep;32(9):743-9. |
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b) 動物摘出血管 (Ex Vivo) |
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Vasodilatory mechanism of unoprostone isopropyl on isolated rabbit ciliary artery. |
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Yoshitomi T, Yamaji K, Ishikawa H, Ohnishi Y. |
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Curr Eye Res. 2004 Mar;28(3):167-74. |
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Comparison of the vasoactive effects of the docosanoid unoprostone and selected prostanoids on isolated perfused retinal arterioles. |
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Yu DY, Su EN, Cringle SJ, Schoch C, Percicot CP, Lambrou GN. |
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Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1499-504. |
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Effects of isopropyl unoprostone on rabbit ciliary artery. |
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Hayashi E, Yoshitomi T, Ishikawa H, Hayashi R, Shimizu K. |
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Jpn J Ophthalmol. 2000 May-Jun;44(3):214-20. |
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c) 人眼 (Human eyes) |
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Effect of topical unoprostone isopropyl on optic nerve head circulation in controls and in normal-tension glaucoma patients. |
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Kimura I, Shinoda K, Tanino T, Ohtake Y, Mashima Y. |
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Jpn J Ophthalmol. 2005 Jul-Aug;49(4):287-93. |
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Long-term effect of topically applied isopropyl unoprostone on microcirculation in the human ocular fundus. |
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Makimoto Y, Sugiyama T, Kojima S, Azuma I. |
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Jpn J Ophthalmol. 2002 Jan-Feb;46(1):31-5. |
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Partial antagonism of endothelin 1-induced vasoconstriction in the human choroid by topical unoprostone isopropyl. |
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Polska E, Doelemeyer A, Luksch A, Ehrlich P, Kaehler N, Percicot CL, Lambrou GN, Schmetterer L. |
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Arch Ophthalmol. 2002 Mar;120(3):348-52. (Also see Anti-Endothelin Function) |
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Effect of topical unoprostone on circulation of human optic nerve head and retina. |
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Tamaki Y, Araie M, Tomita K, Nagahara M, Sandoh S, Tomidokoro A. |
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J Ocul Pharmacol Ther. 2001 Dec;17(6):517-27. |
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| 3. |
作用機序関連 (Mechanism) |
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a) In Vivo |
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Increase in outflow facility with unoprostone treatment in ocular hypertensive patients. |
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Toris CB, Zhan G, Camras CB. |
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Arch Ophthalmol. 2004 Dec;122(12):1782-7. |
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Intraocular metabolites of isopropyl unoprostone. |
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Numaga J, Koseki N, Kaburaki T, Kawashima H, Tomita G, Araie M. |
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Curr Eye Res. 2005 Oct;30(10):909-13. |
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b) In Vitro |
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Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells. |
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Ooi YH, Oh DJ, Rhee DJ. |
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Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5259-65 |
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Cat iris sphincter smooth-muscle contraction: comparison of FP-class prostaglandin analog agonist activities. |
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Sharif NA, Kaddour-Djebbar I, Abdel-Latif AA. |
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J Ocul Pharmacol Ther. 2008 Apr;24(2):152-63. |
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|
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Cellular and molecular effects of unoprostone as a BK channel activator. |
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Cuppoletti J, Malinowska DH, Tewari KP, Chakrabarti J, Ueno R. |
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Biochim Biophys Acta. 2007 May;1768(5):1083-92. |
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The effects of prostaglandin analogues on prostanoid EP1, EP2, and EP3 receptor-deficient mice. |
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Ota T, Aihara M, Saeki T, Narumiya S, Araie M. |
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Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3395-9. |
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The effect of unoprostone isopropyl on Ca2+ release-activated Ca2+ currents in cultured monkey trabecular meshwork cells and ciliary muscle cells. |
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Shimura M, Yasuda K, Nakzawa T, Kashiwagi K. |
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J Ocul Pharmacol Ther. 2006 Aug;22(4):219-26. |
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The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice. |
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Ota T, Aihara M, Narumiya S, Araie M. |
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Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4159-63. |
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Effects of unoprostone and endothelin 1 on L-type channel currents in human trabecular meshwork cells. |
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Thieme H, Steinhausen K, Ottlecz A, Lambrou GN, Strauss O, Wiederholt M, Rosenthal R. |
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Ophthalmic Res. 2005 Nov-Dec;37(6):293-300. |
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Human ciliary muscle cell responses to FP-class prostaglandin analogs: phosphoinositide hydrolysis, intracellular Ca2+ mobilization and MAP kinase activation. |
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Sharif NA, Crider JY, Husain S, Kaddour-Djebbar I, Ansari HR, Abdel-Latif AA. |
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J Ocul Pharmacol Ther. 2003 Oct;19(5):437-55 |
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Comparison between isopropyl unoprostone and latanoprost by prostaglandin E(2)induction, affinity to prostaglandin transporter, and intraocular metabolism. |
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Kashiwagi K, Kanai N, Tsuchida T, Suzuki M, Iizuka Y, Tanaka Y, Tsukahara S. |
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Exp Eye Res. 2002 Jan;74(1):41-9. |
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Studies on receptor binding and signal transduction pathways of unoprostone isopropyl. |
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Bhattacherjee P, Paterson CA, Percicot C. |
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J Ocul Pharmacol Ther. 2001 Oct;17(5):433-41. |
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Mechanisms of action of unoprostone on trabecular meshwork contractility. |
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Thieme H, Stumpff F, Ottlecz A, Percicot CL, Lambrou GN, Wiederholt M. |
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Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3193-201 |
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| 4. |
抗エンドセリン作用 (Anti-Endothelin Function) |
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Effect of unoprostone on topographic and blood flow changes in the ischemic optic nerve head of rabbits. |
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Sugiyama T, Mashima Y, Yoshioka Y, Oku H, Ikeda T. |
| |
Arch Ophthalmol. 2009 Apr;127(4):454-9. |
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|
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Effects of unoprostone on phosphorylated extracellular signal-regulated kinase expression in endothelin-1-induced retinal and optic nerve damage. |
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Munemasa Y, Kitaoka Y, Hayashi Y, Takeda H, Fujino H, Ohtani-Kaneko R, Hirata K, Ueno S. |
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Vis Neurosci. 2008 Mar-Apr;25(2):197-208. |
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Effects of topically instilled bunazosin hydrochloride and other ocular hypotensive drugs on endothelin-1-induced constriction in rabbit retinal arteries. |
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Okada Y, Ichikawa M, Ishii K, Hara H. |
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Jpn J Ophthalmol. 2004 Sep-Oct;48(5):465-9. |
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Inhibition of endothelin-1 and KCL-induced increase of [CA2+]i by antiglaucoma drugs in cultured A7r5 vascular smooth-muscle cells. |
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Wu KY, Wang HZ, Hong SJ. |
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J Ocul Pharmacol Ther. 2004 Jun;20(3):201-9. |
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|
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Partial antagonism of endothelin 1-induced vasoconstriction in the human choroid by topical unoprostone isopropyl. |
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Polska E, Doelemeyer A, Luksch A, Ehrlich P, Kaehler N, Percicot CL, Lambrou GN, Schmetterer L. |
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Arch Ophthalmol. 2002 Mar;120(3):348-52. |
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| 5. |
臨床 (Clinical Study) |
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[Long-term effects of isopropyl unoprostone monotherapy on intraocular pressure and visual field for normal-tension glaucoma and primary open-angle glaucoma patients] |
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Saito Y, Saeki T, Sugiyama K. |
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Nippon Ganka Gakkai Zasshi. 2006 Sep;110(9):717-22. Japanese. |
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Rescula as an alternative therapy for beta-blockers with long-term drift effect in glaucoma patients. |
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Chen CL, Tseng HY, Wu KY. |
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Kaohsiung J Med Sci. 2006 Jun;22(6):266-70. |
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The efficacy of unoprostone isopropyl as an adjunct to topical beta-blocker in patients with open angle glaucoma: a-6-month study. |
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Leelachaikul Y, Euswas A. |
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J Med Assoc Thai. 2005 Nov;88 Suppl 9:S100-4. |
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Blood-aqueous barrier changes after the use of prostaglandin analogues in patients with pseudophakia and aphakia: a 6-month randomized trial. |
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Arcieri ES, Santana A, Rocha FN, Guapo GL, Costa VP. |
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Arch Ophthalmol. 2005 Feb;123(2):186-92. (Also see Safety and Side Effect) |
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Brimonidine 0.2% vs unoprostone 0.15% both added to timolol maleate 0.5% given twice daily to patients with primary open-angle glaucoma or ocular hypertension. |
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Sharpe ED, Henry CJ, Mundorf TK, Day DG, Stewart JA, Jenkins JN, Stewart WC. |
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Eye (Lond). 2005 Jan;19(1):35-40. |
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The safety and efficacy of unoprostone 0.15% versus brimonidine 0.2%. |
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Stewart WC, Stewart JA, Day DG, Jenkins J. |
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Acta Ophthalmol Scand. 2004 Apr;82(2):161-5. |
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Unoprostone isopropyl pretreatment decreases endothelin-1 release and the intra-ocular pressure spike induced by laser trabeculoplasty in the rabbit. |
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Holló G, Visontai Z, Lakatos P, Vargha P. |
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Ophthalmologica. 2003 May-Jun;217(3):231-6. |
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Timolol 0.5%/dorzolamide 2% fixed combination vs timolol maleate 0.5% and unoprostone 0.15% given twice daily to patients with primary open-angle glaucoma or ocular hypertension. |
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Day DG, Schacknow PN, Wand M, Sharpe ED, Stewart JA, Leech J, Stewart WC. |
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Am J Ophthalmol. 2003 Feb;135(2):138-43. |
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A double-masked randomized comparison of the efficacy and safety of unoprostone with timolol and betaxolol in patients with primary open-angle glaucoma including pseudoexfoliation glaucoma or ocular hypertension. 6 month data. |
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Nordmann JP, Mertz B, Yannoulis NC, Schwenninger C, Kapik B, Shams N; Unoprostone Monotherapy Study Group-EU. |
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Am J Ophthalmol. 2002 Jan;133(1):1-10. |
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Additive efficacy of unoprostone isopropyl 0.12% (rescula) to latanoprost 0.005%. |
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Stewart WC, Sharpe ED, Stewart JA, Holmes KT, Latham KE. |
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Am J Ophthalmol. 2001 Mar;131(3):339-44. |
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| 6. |
副作用 (Safety and Side Effect) |
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Blood-aqueous barrier changes after the use of prostaglandin analogues in patients with pseudophakia and aphakia: a 6-month randomized trial. |
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Arcieri ES, Santana A, Rocha FN, Guapo GL, Costa VP. |
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Arch Ophthalmol. 2005 Feb;123(2):186-92. |
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Low incidence of iris pigmentation and eyelash changes in 2 randomized clinical trials with unoprostone isopropyl 0.15%. |
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McCarey BE, Kapik BM, Kane FE; Unoprostone Monotherapy Study Group. |
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Ophthalmology. 2004 Aug;111(8):1480-8. |
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Comparison of iridial pigmentation between latanoprost and isopropyl unoprostone: a long term prospective comparative study. |
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Chiba T, Kashiwagi K, Chiba N, Ishijima K, Furuichi M, Kogure S, Abe K, Tsukahara S. |
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Br J Ophthalmol. 2003 Aug;87(8):956-9. |
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Safety of unoprostone isopropyl 0.15% ophthalmic solution in patients with mild to moderate asthma. |
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Gunawardena KA, Crame N, Mertz B, Shams N. |
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Ophthalmologica. 2003 Mar-Apr;217(2):129-36. |
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Safety of unoprostone isopropyl as mono- or adjunctive therapy in patients with primary open-angle glaucoma or ocular hypertension. |
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de Arruda Mello PA, Yannoulis NC, Haque RM. |
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Drug Saf. 2002;25(8):583-97. Review. |
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Comparison of the cardiovascular effects of unoprostone 0.15%, timolol 0.5% and placebo in healthy adults during exercise using a treadmill test. |
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Stewart WC, Stewart JA, Crockett S, Kubilus C, Brown A, Shams N. |
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Acta Ophthalmol Scand. 2002 Jun;80(3):272-6. |
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New glaucoma medications in the geriatric population: efficacy and safety. |
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Novack GD, O'Donnell MJ, Molloy DW. |
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J Am Geriatr Soc. 2002 May;50(5):956-62. Review. |
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Effects of topical unoprostone and latanoprost on acute and recurrent herpetic keratitis in the rabbit. |
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Kaufman HE, Varnell ED, Toshida H, Kanai A, Thompson HW, Bazan NG. |
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Am J Ophthalmol. 2001 May;131(5):643-6. |
